' 
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.3
USERS' SCORE
Very Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
4
Vitamin D3 does not prevent stones
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.
Highly relevant to kidney stones
We assessed how two different vitamin D3 repletion protocols affect patients with recurrent calcium kidney stones and vitamin D deficiency. This was a controlled clinical trial involving 62 participants who had low levels of vitamin D and were prone to kidney stones. We administered either 2000 IU of cholecalciferol daily for 12 weeks or 50,000 IU weekly for 8 weeks.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
Read More
4
Vitamin D3 increases kidney stone risk
Metabolic effects of cholecalciferol supplementation in patients with calcium nephrolithiasis and vitamin D deficiency.
Relevant study on vitamin D3
We explored the impact of cholecalciferol, also known as vitamin D3, on individuals with calcium nephrolithiasis and a deficiency in vitamin D. The purpose of our investigation was to determine whether this supplementation might lead to an increased risk of developing kidney stones.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
Read More
5
Vitamin D3: Monitoring Calcium Excretion
Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk?
Direct link to kidney stone risk
We explored the connection between vitamin D3 supplementation and kidney stones in individuals with no identifiable causes for their stones. Our study examined a group of 456 idiopathic stone formers to find out how prevalent vitamin D deficiency is among them. We discovered that a significant portion—31%—were deficient in vitamin D, while 57% were insufficient, and only 12% were at healthy levels.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
Read More
Most Useful Reviews
9.5
High dosage recommendation
This product is excellent for its strength of 50,000 units per week. One pill is sufficient, and its oily texture seems better for kidney health.
Read More
9.5
Improved kidney health
Having researched high-dose vitamin D3, I find these capsules beneficial. I've noticed my skin is soft and hydrated, no longer needing constant hand cream. My left thumb pain has disappeared, and I believe the combination of vitamin D3 and K2 helps guide calcium appropriately, reducing the risk of kidney stones. I take higher doses as recommended for my health, aware that autoimmune diseases are linked to low vitamin D3 levels.
Read More
8.8
Supports kidney function
Those with vitamin D deficiency should combine it with K2 to avoid recurring symptoms. This product is high-quality and reasonably priced, strongly boosting immunity and promoting healthy bones and joints. However, I advise caution with high doses, especially for anyone with kidney or liver problems.
Read More
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Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.3
5
Vitamin D3: Monitoring Calcium Excretion
Vitamin D deficiency is prevalent among idiopathic stone formers, but does correction pose any risk?
Direct link to kidney stone risk
We explored the connection between vitamin D3 supplementation and kidney stones in individuals with no identifiable causes for their stones. Our study examined a group of 456 idiopathic stone formers to find out how prevalent vitamin D deficiency is among them. We discovered that a significant portion—31%—were deficient in vitamin D, while 57% were insufficient, and only 12% were at healthy levels.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
To see if supplementing vitamin D3 would provide benefits, we gave 37 of these vitamin D-deficient patients a weekly dose of 20,000 IU for four months. While we noted that this supplementation raised serum vitamin D levels and reduced parathyroid hormone concentrations, the increase in urinary calcium excretion after treatment did not reach statistical significance.
Interestingly, 22 patients had higher calcium levels in their urine, but others experienced a decrease or no change. What’s crucial here is that six patients who were initially normal concerning calcium levels ended up developing hypercalciuria after treatment. This means we should carefully monitor patients who receive vitamin D3 to ensure that they do not experience unexpected increases in calcium excretion that could raise the risk of kidney stones.
Read More
4
Vitamin D3 does not prevent stones
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.
Highly relevant to kidney stones
We assessed how two different vitamin D3 repletion protocols affect patients with recurrent calcium kidney stones and vitamin D deficiency. This was a controlled clinical trial involving 62 participants who had low levels of vitamin D and were prone to kidney stones. We administered either 2000 IU of cholecalciferol daily for 12 weeks or 50,000 IU weekly for 8 weeks.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
Read More
4
Vitamin D3 increases kidney stone risk
Metabolic effects of cholecalciferol supplementation in patients with calcium nephrolithiasis and vitamin D deficiency.
Relevant study on vitamin D3
We explored the impact of cholecalciferol, also known as vitamin D3, on individuals with calcium nephrolithiasis and a deficiency in vitamin D. The purpose of our investigation was to determine whether this supplementation might lead to an increased risk of developing kidney stones.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
In the study, thirty-three participants, averaging 56 years and deficient in vitamin D, were evaluated before and after receiving cholecalciferol supplements. Initially, we examined both their calcium excretion and urine supersaturation levels, which help indicate the risk of stone formation.
Following the supplementation, we observed several significant changes. Notably, the serum levels of vitamin D increased, and more participants became hypercalciuric, meaning they were excreting higher levels of calcium in their urine. This was concerning as increased urine supersaturation with calcium could elevate the risk of kidney stones.
Despite the rise in vitamin D levels, we didn’t see any major changes in overall calcium levels in the blood, suggesting that the body was managing these variations. However, for those undergoing this treatment, there remains a cautionary note about the potential for increased stone formation due to higher calcium excretion.
Read More
4
Vitamin D3 increases kidney stone risk
[Metabolic effects of Cholecalciferol supplementation in kidney stone formers with vitamin D deficiency].
Research shows potential risks
We explored the effects of cholecalciferol, or vitamin D3, on kidney stone formers dealing with vitamin D deficiency. Our study involved 33 participants, where we evaluated their calcium excretion and urine supersaturation with calcium oxalate and brushite both before and after vitamin D3 supplementation. Participants received a high initial dose followed by regular maintenance doses, all while adhering to a structured diet with a controlled amount of calcium intake.
After the supplementation, we observed some notable changes. While serum calcium and phosphate levels remained stable, the level of vitamin D3 in the blood saw a significant increase. This led to more kidney stone formers experiencing higher urinary calcium levels. Notably, the percentage of participants with hypercalciuria grew from 18.2% to 39.4%. We also noted an increase in urine supersaturation for brushite, hinting at a potential risk for stone formation.
Overall, our findings suggest that while vitamin D3 supplementation can elevate vitamin D levels, it may also increase urinary calcium and the risk of recurrences for kidney stones. Consequently, careful monitoring of urinary metabolic profiles for patients receiving vitamin D may be necessary to tailor preventive strategies effectively.
After the supplementation, we observed some notable changes. While serum calcium and phosphate levels remained stable, the level of vitamin D3 in the blood saw a significant increase. This led to more kidney stone formers experiencing higher urinary calcium levels. Notably, the percentage of participants with hypercalciuria grew from 18.2% to 39.4%. We also noted an increase in urine supersaturation for brushite, hinting at a potential risk for stone formation.
Overall, our findings suggest that while vitamin D3 supplementation can elevate vitamin D levels, it may also increase urinary calcium and the risk of recurrences for kidney stones. Consequently, careful monitoring of urinary metabolic profiles for patients receiving vitamin D may be necessary to tailor preventive strategies effectively.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 7 Reviews
8.1
9.5
Improved kidney health
Having researched high-dose vitamin D3, I find these capsules beneficial. I've noticed my skin is soft and hydrated, no longer needing constant hand cream. My left thumb pain has disappeared, and I believe the combination of vitamin D3 and K2 helps guide calcium appropriately, reducing the risk of kidney stones. I take higher doses as recommended for my health, aware that autoimmune diseases are linked to low vitamin D3 levels.
Read More
9.5
High dosage recommendation
This product is excellent for its strength of 50,000 units per week. One pill is sufficient, and its oily texture seems better for kidney health.
9
Effective for bones
The quality is good, and I've noticed improvements in my immunity and bone health. The dosage is safe for those lacking sun exposure, and it has helped reduce my kidney stones significantly since I started using it.
8.8
Supports kidney function
Those with vitamin D deficiency should combine it with K2 to avoid recurring symptoms. This product is high-quality and reasonably priced, strongly boosting immunity and promoting healthy bones and joints. However, I advise caution with high doses, especially for anyone with kidney or liver problems.
Read More
8
Skin and nails improvement
I recommend analysing vitamin D levels before taking it. My doctor prescribed a weekly dose. Since I started, I've noticed improvements in my skin, hair, and mood. I'm hopeful this will help with my severe deficiency and the issues it caused, including better management of kidney stones.
Read More
